2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Aminoacyl-tRNA Synthetase

Aminoacyl-tRNA Synthetase

tRNA Synthetase, aaRS

Aminoacyl-tRNA Synthetase

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Aminoacyl-tRNA synthetases (AARSs) are the enzymes that catalyze the aminoacylation reaction by covalently linking an amino acid to its cognate tRNA in the first step of protein translation. In mammals, AARSs usually exist in free form or in the form of a multi-tRNA synthetase complex (MSC), and the latter consists of eight AARSs and three non-enzymatic AARS-interacting multi-functional proteins (AIMP1/p43, AIMP2/p38, and AIMP3/p18).

AARSs are responsible for the proper pairing of codons on mRNA with amino acids. AARSs are also involved in RNA splicing, transcriptional regulation, translation, and other aspects of cellular homeostasis. Study of these enzymes is of great interest to the researchers due to its pivotal role in the growth and survival of an organism. AARSs are one of the leading targets for developing novel anti-infective agents. Further, unfolding the interesting structural and functional aspects of these enzymes in the last few years has qualified them as a potential drug target against various diseases.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W108875R
    Mupirocin lithium (Standard)
    		Inhibitor
    Mupirocin (lithium) (Standard) is the analytical standard of Mupirocin lithium (HY-W108875). This product is intended for research and analytical applications. Mupirocin lithium is an antibiotic. Mupirocin lithium inhibits bacterial isoleucyl-tRNA synthetase, blocking protein synthesis. Mupirocin lithium has high activity against Gram-positive bacteria such as Staphylococcus and Streptococcus, as well as some Gram-negative bacteria (such as Haemophilus influenzae). Mupirocin lithium can be used in the research of diseases such as skin infections (such as MRSA infections) and chronic sinusitis.
    Mupirocin lithium (Standard)
  • HY-159627
    Met-AMS
    		Inhibitor
    Met-AMS (Compound 50) is a sulfonamide analog of methionyl-adenylate (Met-AMP) and an inhibitor of isoleucyl-tRNA synthetase (IleRS) with an IC50 of 7 nM.
    Met-AMS
  • HY-168569
    DDD489
    		Inhibitor
    DDD489 is a potent and selective Cryptosporidium lysyl-tRNA synthetase (CpKRS) inhibitor with IC50 values of 0.85 uM.DDD489 shows anti-cryptosporidials activity in vitro and in vivo.
    DDD489
  • HY-B0958R
    Mupirocin (Standard)
    		Inhibitor
    Mupirocin (Standard) is the analytical standard of Mupirocin (HY-B0958). This product is intended for research and analytical applications. Mupirocin is an antibiotic. Mupirocin inhibits bacterial isoleucyl-tRNA synthetase, blocking protein synthesis. Mupirocin has high activity against Gram-positive bacteria such as Staphylococcus and Streptococcus, as well as some Gram-negative bacteria (such as Haemophilus influenzae). Mupirocin can be used in the research of diseases such as skin infections (such as MRSA infections) and chronic sinusitis.
    Mupirocin (Standard)
  • HY-161797
    Antibacterial agent 227
    		Inhibitor
    Antibacterial agent 227 (Compd 29) is a SerRS (Seryl-tRNA synthetase) inhibitor. Antibacterial agent 227 has a significant inhibitory effect on the growth of planktonic and biofilm culture of Staphylococcus aureus 25923 with MIC (minimum inhibitory concentration) value of 32 µg/ml. Antibacterial agent 227 can be proposed as effective antiseptic toward multidrug-resistant biofilm-forming S. aureus isolates.
    Antibacterial agent 227
  • HY-183004
    NCP26
    		Inhibitor
    NCP26 is an ATP-competitive ProRS inhibitor (with a KD of 271 nM in the absence of proline, and a KD of 0.35 nM in the presence of 100 μM proline). NCP26 activates AAR, induces G0/G1 phase arrest, Apoptosis, Caspase cleavage, and PARP cleavage. NCP26 downregulates MYC, TCF3, and CCND1. NCP26 inhibits the growth of multiple myeloma cells. NCP26 can be used for the research of multiple myeloma.
    NCP26
  • HY-108939R
    Aminoacyl tRNA synthetase-IN-1 (Standard)
    		Inhibitor
    Aminoacyl tRNA synthetase-IN-1 (Standard) is the analytical standard of Aminoacyl tRNA synthetase-IN-1 (HY-108939). This product is intended for research and analytical applications. Aminoacyl tRNA synthetase-IN-1 is a bacterial aminoacyl tRNA synthetase (aaRS) inhibitor. Aminoacyl tRNA synthetase-IN-1 has inhibitory activity against S. aureus, E. faecalis and E.coli.
    Aminoacyl tRNA synthetase-IN-1 (Standard)
  • HY-W014233R
    L-Histidinol dihydrochloride (Standard)
    		Inhibitor
    L-Histidinol (dihydrochloride) (Standard) is the analytical standard of L-Histidinol (dihydrochloride) (HY-W014233). This product is intended for research and analytical applications. L-Histidinol dihydrochloride is an orally active histidyl-tRNA synthetase inhibitor. L-Histidinol dihydrochloride interferes with the initiation stage of protein synthesis, thus affecting cell proliferation and metabolism. L-Histidinol dihydrochloride has the effect of modulating the sensitivity of tumor cells to chemotherapeutic agents. L-Histidinol dihydrochloride reduces the toxicity of certain chemotherapeutic agents to normal tissues and enhance the sensitivity of tumor cells to chemotherapeutic agents.
    L-Histidinol dihydrochloride (Standard)
  • HY-159628
    Glu-AMS
    		Inhibitor
    Glu-AMS is a competitive inhibitor of Escherichia coli glutamyl-tRNA synthetase (GluRS), with the Ki of 2.8 nM.
    Glu-AMS
  • HY-108900R
    Leu-AMS (Standard)
    		Inhibitor
    Leu-AMS (Standard) is the analytical standard of Leu-AMS (HY-108900). This product is intended for research and analytical applications. Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation. Leu-AMS shows cytotoxicity in cancer cells and normal cells, and inhibits the growth of bacteria.
    Leu-AMS (Standard)
  • HY-128189
    Aminoacyl tRNA synthetase-IN-4
    		Inhibitor
    Aminoacyl tRNA synthetase-IN-4 (Compound 1l) is an inhibitor of Aminoacyl tRNA synthetase, with an IC50 of 0.026 μM for C.albicans prolyl-tRNA synthetase. Aminoacyl tRNA synthetase-IN-4 can be used for antifungal research.
    Aminoacyl tRNA synthetase-IN-4
  • HY-12479B
    Epetraborole (R-mandelate)
    		Inhibitor
    Epetraborole R-mandelate is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole R-mandelate can be used in multidrug-resistant gram-negative pathogens infection research.
    Epetraborole (R-mandelate)
  • HY-W275220
    PEA-NBOMe hydrochloride
    		Inhibitor
    PEA-NBOMe hydrochloride (Compound 21) is a competitive phenylalanyl-tRNA synthetase (PRS) inhibitor (Ki=0.92 μM), which is found in Escherichia coli. PEA-NBOMe hydrochloride is promising for research of antibacterial or antiviral agents.
    PEA-NBOMe hydrochloride
  • HY-161800
    Aminoacyl tRNA synthetase-IN-3
    		Inhibitor
    Aminoacyl tRNA synthetase-IN-3 (compound 36K3) is an inhibitor of lysine tRNA synthetase (PfLysRS) from Plasmodium falciparum (IC50=59.2 nM), which inhibits the activity of PfLysRS by occupying the ATP binding site and L-lysine binding site of PfLysRS. Aminoacyl tRNA synthetase-IN-3 can be used in the development of antimalarial drugs.
    Aminoacyl tRNA synthetase-IN-3
Cat. No. Product Name / Synonyms Application Reactivity